HBV|HBV-TG疾病模型小鼠

品系介绍

品系全名：B6.Cg-Tg(HBV)Smoc

目录号：NM-TG-00003

品系状态：活体

将c1型HBV病毒1.0拷贝全长DNA转入小鼠，该转基因小鼠血清中HBsAg呈阳性，但无HBeAg、anti-HBs、anti-HBe或antiHBc表达，无HBV DNA。在该转基因小鼠模型的血清、肝脏和肾脏中可以检测到稳定表达的人乙肝病毒表面抗原，该小鼠模型为研究人类“乙型肝炎”的发病机制、治疗方法与药物筛选，提供了理想的动物模型和新型研究手段，具有重要的医药应用价值。

基本信息

基因名：HBV

基因曾用名：Hepatitis B virus isolate C8 complete genome

NCBI ID：AF461363

MGI ID：Null

Ensembl ID：Null

Pubmed：HBV

相关数据

Fig1. Immuno-histochemical staining of HBsAg in the liver and kidney sections of 59 transgenic mice. Sections of liver (A) or kidney (B) tissues from 59 transgenic mice were stained for HBsAg.

Fig2.  Immuno-histochemical staining of HBcAg in the liver and kidney sections of 59 transgenic mice.

Sections of liver (A) or kidney (B) tissues from 59 transgenic mice were stained for HBcAg.

Tab1. Eight Selected Genes From the Kidney of 59 Mice Assayed by Microarray and Real-Time PCR

Fig3.  Dot blot immunoassay of complement C3 component in mouse serum and kidney tissue extract.

Reference

1. Ren J, Wang L, Chen Z, Ma ZM, Zhu HG, Yang DL, Li XY, Wang BI, Fei J, Wang ZG, Wen YM. Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy. J Med Virol. 2006 May;78(5):551-60. doi: 10.1002/jmv.20575. PMID: 16555286.

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