hPD-L1(2)

品系介绍

品系全名：C57BL/6JSmoc-Cd274^{em2(hPD-L1)Smoc}

目录号：NM-HU-190039

品系状态：活体

通过同源重组，将小鼠基因Cd274进行人源化修饰。与此相似的品系还有hPD-L1(NM-HU-00062),详细信息请咨询技术顾问。

基本信息

基因名：Cd274

基因曾用名：B7h1， Pdl1， Pdcd1l1，Pdcd1lg1， A530045L16Rik

NCBI ID：60533

MGI ID：1926446

Ensembl ID：ENSMUSG00000016496

Pubmed：Cd274

人类同源基因：CD274

相关数据

Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice. 

Fig3. Immunotype in blood in hPD-L1 mice. 

Fig4. Immunotype in spleen in hPD-L1 mice. 

Fig5. Immunotype in bone marrow in hPD-L1 mice. 

Fig6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.

相关品系

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hPD-L1/hCD28品系名：C57BL/6JSmoc-Cd274^em1(hPD-L1)Cd28^{em2(hCD28)Smoc}品系状态：活体 | 目录号：NM-HU-210019

Cd274-Flox品系名：C57BL/6JSmoc-Cd274^{em1(flox)Smoc}品系状态：活体 | 目录号：NM-CKO-200298

Cd274-KO(2)品系名：C57BL/6JSmoc-Cd274^em2Smoc品系状态：活体 | 目录号：NM-KO-18044