注意:因业务调整,暂不接受个人委托测试望见谅。
品系全名:C57BL/6JSmoc-Cd274em1(hPD-L1)Smoc
目录号:NM-HU-00062
品系状态:活体
通过同源重组,将小鼠基因Cd274进行人源化修饰。与此相似的品系还有hPD-L1(2)(NM-HU-190039),详细信息请咨询技术顾问。
基因名:Cd274
基因曾用名:B7h1, Pdl1, Pdcd1l1,Pdcd1lg1, A530045L16Rik
NCBI ID:60533
MGI ID:1926446
Ensembl ID:ENSMUSG00000016496
Pubmed:Cd274
人类同源基因:CD274
Fig1. Expression of PD-L1 in the spleen lymphocytes collected from homozygous humanized PD-L1 mice and wild-type mice is detected by FACS. The results showed that the expression of human PD-L1 can be detected in both T cells and B cells collected from the spleen of homozygous humanized PD-L1 mice. (Completed in collaboration with CrownBio)
Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.
Fig3. Immunotype in blood in hPD-L1 mice.
Fig4. Immunotype in spleen in hPD-L1 mice.
Fig5. Immunotype in bone marrow in hPD-L1 mice.
Fig6. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized PD-L1 mice. Homozygous humanized PD-L1 mice were inoculated with MC38 colon cancer cells (expressing human PDL1 rather than murine PD-L1). After the tumors grew to 100 mm3, the animals were randomly assigned into a control group and a treatment group (n=5). The results showed: The antibodies targeting human PD-L1 were associated with a very significant anti-tumor effect (TGI: tumor growth inhibition, p < 0.001), demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1.
hCD274(BALB/c)品系名:BALB/cAnSmoc-Cd274em1(hCD274)Smoc品系状态:在研 | 目录号:NM-HU-230465
hPD-L1(BALB/c,2)品系名:BALB/cAnSmoc-Cd274em2(hPD-L1)Smoc品系状态:在研 | 目录号:NM-HU-230474
hPD-L1/hCD28品系名:C57BL/6JSmoc-Cd274em1(hPD-L1)Cd28em2(hCD28)Smoc品系状态:活体 | 目录号:NM-HU-210019
Cd274-Flox品系名:C57BL/6JSmoc-Cd274em1(flox)Smoc品系状态:活体 | 目录号:NM-CKO-200298
hPD-L1(2)品系名:C57BL/6JSmoc-Cd274em2(hPD-L1)Smoc品系状态:活体 | 目录号:NM-HU-190039
1.具体的试验周期以工程师告知的为准。
2.文章中的图片或者标准以及具体的试验方案仅供参考,因为每个样品和项目都有所不同,所以最终以工程师告知的为准。
3.关于(样品量)的需求,最好是先咨询我们的工程师确定,避免不必要的样品损失。
4.加急试验周期一般是五个工作日左右,部分样品有所差异
5.如果对于(hPD-L1)还有什么疑问,可以咨询我们的工程师为您一一解答。