注意:因业务调整,暂不接受个人委托测试望见谅。
品系全名:C57BL/6JSmoc-Cd274em2(hPD-L1)Smoc
目录号:NM-HU-190039
品系状态:活体
通过同源重组,将小鼠基因Cd274进行人源化修饰。与此相似的品系还有hPD-L1(NM-HU-00062),详细信息请咨询技术顾问。
基因名:Cd274
基因曾用名:B7h1, Pdl1, Pdcd1l1,Pdcd1lg1, A530045L16Rik
NCBI ID:60533
MGI ID:1926446
Ensembl ID:ENSMUSG00000016496
Pubmed:Cd274
人类同源基因:CD274
Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis.
Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.
Fig3. Immunotype in blood in hPD-L1 mice.
Fig4. Immunotype in spleen in hPD-L1 mice.
Fig5. Immunotype in bone marrow in hPD-L1 mice.
Fig6. In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A) PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice. All quantitative data are represented as mean ± SEM.
hCD274(BALB/c)品系名:BALB/cAnSmoc-Cd274em1(hCD274)Smoc品系状态:在研 | 目录号:NM-HU-230465
hPD-L1(BALB/c,2)品系名:BALB/cAnSmoc-Cd274em2(hPD-L1)Smoc品系状态:在研 | 目录号:NM-HU-230474
hPD-L1/hCD28品系名:C57BL/6JSmoc-Cd274em1(hPD-L1)Cd28em2(hCD28)Smoc品系状态:活体 | 目录号:NM-HU-210019
Cd274-Flox品系名:C57BL/6JSmoc-Cd274em1(flox)Smoc品系状态:活体 | 目录号:NM-CKO-200298
Cd274-KO(2)品系名:C57BL/6JSmoc-Cd274em2Smoc品系状态:活体 | 目录号:NM-KO-18044
1.具体的试验周期以工程师告知的为准。
2.文章中的图片或者标准以及具体的试验方案仅供参考,因为每个样品和项目都有所不同,所以最终以工程师告知的为准。
3.关于(样品量)的需求,最好是先咨询我们的工程师确定,避免不必要的样品损失。
4.加急试验周期一般是五个工作日左右,部分样品有所差异
5.如果对于(hPD-L1(2))还有什么疑问,可以咨询我们的工程师为您一一解答。
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